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Dr Mallika Lavania

HomeDr Mallika Lavania
HomeDr Mallika Lavania
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Dr Mallika Lavania

Designation: Scientist E and Group Leader

Division: Enteric Viruses Group

Educational qualifications: PhD

Date of joining ICMR-NIV: :27th January 2020

  • Contact: +91-020-26006215
  • Email: mallikalavania@gmail.com
  • Office: Indian Council of Medical Research-National Institute of Virology Pune Maharashtra - 411001

 

Research Interests:

  • Molecular Diagnostics and Molecular Epidemiology of infectious diseases
  • Genomics & Pathogenesis, Antimicrobial Drug Resistance

 

Awards/Honours:

  • Awarded Best poster Award by Indian Association of Leprologists in 2006
  • Awarded Young Scientist Award in 2007 by Indian Association of Leprologists
  • Awarded Best Oral Presentation Award by Indian Association of Leprologists in 2009
  • Awarded Acworth Memorial Award for the best publication in 2012 by Indian Association of Leprologists
  • Awarded ICMR JALMA Trust Fund Oration Award (Leprosy and other mycobacterial diseases) for the contributions in the field of leprosy research for the year 2020 from Indian Council of Medical Research, Department of health Research, Government of India.
  • Awarded Travel Grant from European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Attendance Grants to attend the International Conference on Infectious Disease and Nanomedicine-2015 [ICIDN-2015] to be held during December 15-18, 2015 in Park Village Hotel & Resorts, Budhanilkantha, Kathmandu, Nepal.

 

ORCID ID: 0000-0003-3072-9313

Researcher ID: AAV-5602-2020

Google Scholar Profile Link

 

List of Publications
  • 1. Lavania M, Joshi MS, Ranshing SS, Potdar VA, Shinde M, Chavan N, Jadhav SM, Sarkale P, Mohandas S, Sawant PM, Tikute S, Padbidri V, Patwardhan S, Kate R. Prolonged Shedding of SARS-CoV-2 in Feces of COVID-19 Positive Patients: Trends in Genomic Variation in First and Second Wave. Front Med (Lausanne). 2022 Mar 15;9:835168

    2. Lavania M, Potdar VA, Ranshing S, Vipat V, Saha U, Jadhav SM, Sawant PM, Padbidri V, Chaudhari PA, Patwardhan S. Whole-genome sequencing & mutational analysis of SARS-CoV-2 from patients' faecal samples reveal the possible role in faecal-oral transmission. Indian J Med Res. 2022 Apr 29. doi: 10.4103/ijmr.ijmr_1045_21. Epub ahead of print.

    3. Narang T, Kamat D, Thakur V, Lavania M, Singh I, Ahuja M, Dogra S. Equal rates of drug resistance in leprosy cases with relapse and recurrent/chronic Type 2 reaction: time to revise the guidelines for drug-resistance testing in leprosy? Clin Exp Dermatol. 2022 Feb;47(2):297-302.

    4. Lavania, Mallika; Viswanathan, Rajlakshmi; Bhardwaj, Sumit Dutt; Oswal, Jitendra S; Chavan, Nutan; Shinde, Manohar; Katendra, Savita; Manuscript type: Case report Title: Detection of Echovirus-18 in children suspected with COVID-19 with multisystem inflammatory syndrome-report from India. Frontiers in Public Health [Accepted]

    5. Ahuja M, Singh I, Lavania M, Pathak VK, Darlong J, Turankar RP, Hembrom S, Singh SV, Sengupta U. Ofloxacin resistance in multibacillary new leprosy cases from Purulia, West Bengal: A threat to effective secondary line treatment for rifampicin resistant leprosy cases. J Glob Antimicrob Resist. 2022 Jun 15:S2213-7165(22)00141-2.

    6. Ranshing S, Lavania M, Potdar V, Patwardhan S, Prayag PS, Jog S, Kelkar D, Sawant P, Shinde M, Chavan N. Transmission of COVID-19 infection within a family cluster in Pune, India. Indian J Med Res. 2021 May;153(5&6):555-558.

    7. Sardana K, Mathachan SR, Agrawal D, Lavania M, Ahuja M. Late reversal reaction with resistant Mycobacterium leprae: an emerging paradigm. Trop Doct. 2020 Jan;50(1):77-81

    8. Mahajan NP, Lavania M, Singh I, Nashi S, Preethish-Kumar V, Vengalil S, Polavarapu K, Pradeep-Chandra-Reddy C, Keerthipriya M, Mahadevan A, Yasha TC, Nandeesh BN, Gnanakumar K, Parry GJ, Sengupta U, Nalini A. Evidence for Mycobacterium leprae Drug Resistance in a Large Cohort of Leprous Neuropathy Patients from India. Am J Trop Med Hyg. 2020 Mar;102(3):547-552.

    9. Kamat D, Narang T, Ahuja M, Lavania M, Dogra S. Case Report: Multidrug-Resistant Mycobacterium leprae in a Case of Smear-Negative Relapse. Am J Trop Med Hyg. 2020 Apr;102(4):724-727.

    10. Vengalil S, Lavania M, Singh I, Nashi S, Preethish-Kumar V, Polavarapu K, Mahajan NP, Raju S, Pradeep-Chandra-Reddy C, Keerthipriya M, Mahadevan A, Yasha TC, Nandeesh B, Gnanakumar K, Parry GJ, Sengupta U, Nalini A. Appropriately Selected Nerve in Suspected Leprous Neuropathy Yields High Positive Results for Mycobacterium leprae DNA by Polymerase Chain Reaction Method. Am J Trop Med Hyg. 2020 Jul;103(1):209-213.

    11. Jabeen Shumyla, Saini Jitender, Vengalil Seena, Lavania Mallika, Sing, Itu, Nashi Saraswati, Preethish-Kumar Veeramani, Polavarapu Kiran, Mahajan Niranjan Prakash, Mahadevan Anita. Neuroimaging in leprosy: the nerves and beyond. Radiology of Infectious Diseases.2020;7: 12-21.

    12. Sardana K, Kulhari A, Mathachan SR, Khurana A, Bansal P, Ahuja A, Lavania M, Ahuja M. Late leprosy reaction presenting as erythema multiforme-like erythema nodosum leprosum with underlying rifampicin resistance and its potential implications. Int J Mycobacteriol. 2020 Apr-Jun;9(2):226-228.

    13. Mathachan SR, Sardana K, Ahuja A, Lavania M, Agrawal D. Zosteriform multidermatomal nodules and plaques in a case of lepromatous leprosy: an uncommon presentation. Trop Doct. 2020 Oct;50(4):378-380.

    14. Lavania M, Darlong J, Singh I, Ahuja M, Turankar RP, Pathak VK, Kumar A, Nathan R, Sengupta U. Analysis of bacteriological Index between fixed multidrug therapy and new WHO recommended alternative regimen with ofloxacin, minocycline and clofazimine of rifampicin resistant cases from the hospitals of The Leprosy Mission, India. J Glob Antimicrob Resist. 2020 Dec;23:275-277.

    15. Turankar RP, Singh V, Gupta H, Pathak VK, Ahuja M, Singh I, Lavania M, Dinda AK, Sengupta U. Association of non-tuberculous mycobacteria with Mycobacterium leprae in environment of leprosy endemic regions in India. Infect Genet Evol. 2019 Aug;72:191-198.

    16. Turankar RP, Lavania M, Darlong J, Siva Sai KSR, Sengupta U, Jadhav RS. Survival of Mycobacterium leprae and association with Acanthamoeba from environmental samples in the inhabitant areas of active leprosy cases: A cross sectional study from endemic pockets of Purulia, West Bengal. Infect Genet Evol. 2019 Aug;72:199-204.

    17. Polavarapu K, Preethish-Kumar V, Vengalil S, Nashi S, Lavania M, Bhattacharya K, Mahadevan A, Yasha TC, Saini J, Sengupta U, Jabeen S, Nandeesh BN, Singh I, Mahajan NP, Pradeep-Chandra-Reddy C, Parry GJ, Nalini A. Brain and Spinal Cord Lesions in Leprosy: A Magnetic Resonance Imaging-Based Study. Am J Trop Med Hyg. 2019 Apr;100(4):921-931

    18. Pathak VK, Singh I, Turankar RP, Lavania M, Ahuja M, Singh V, Sengupta U. Utility of multiplex PCR for early diagnosis and household contact surveillance for leprosy. Diagn Microbiol Infect Dis. 2019 Nov;95(3):114855.

    19. Sinha S, Sardana K, Agrawal D, Malhotra P, Lavania M, Ahuja M. Multidrug resistance as a cause of steroid-nonresponsive downgrading type I reaction in Hansen's disease. Int J Mycobacteriol. 2019 Jul-Sep;8(3):305-308

    20. Arora Pooja, Sardana, Kabir, Agarwal Aastha, Lavania, Mallika. Resistance as a cause for chronic steroid dependent ENL-a novel paradigm with potential implications in management. Leprosy Review, 2019; 90 :201-205

    21. Lavania Mallika, Darlong Joydeepa, Reddy Abhishek, Ahuja Madhvi, Singh Itu, Turankar RP, Sengupta U. Successful treatment of rifampicin resistant case of leprosy by WHO recommended ofloxacin and minocycline regimen. Leprosy Review,2019; 9: 456-459

    22. Lavania M, Singh I, Turankar RP, Ahuja M, Pathak V, Sengupta U, Das L, Kumar A, Darlong J, Nathan R, Maseey A. Molecular detection of multidrug-resistant Mycobacterium leprae from Indian leprosy patients. J Glob Antimicrob Resist. 2018 Mar;12:214-219.

    23. Lavania M, Singh I, Turankar RP, Gupta AK, Ahuja M, Pathak V, Sengupta U. Enriched whole genome sequencing identified compensatory mutations in the RNA polymerase gene of rifampicin-resistant Mycobacterium leprae strains. Infect Drug Resist. 2018 Jan 25;11:169-175.

    24. Cambau E, Saunderson P, Matsuoka M, Cole ST, Kai M, Suffys P, Rosa PS, Williams D, Gupta UD, Lavania M, Cardona-Castro N, Miyamoto Y, Hagge D, Srikantam A, Hongseng W, Indropo A, Vissa V, Johnson RC, Cauchoix B, Pannikar VK, Cooreman EAWD, Pemmaraju VRR, Gillini L; WHO surveillance network of antimicrobial resistance in leprosy. Antimicrobial resistance in leprosy: results of the first prospective open survey conducted by a WHO surveillance network for the period 2009-15. Clin Microbiol Infect. 2018 Dec;24(12):1305-131

    25. Singh I, Lavania M, Pathak VK, Ahuja M, Turankar RP, Singh V, Sengupta U. VDR polymorphism, gene expression and vitamin D levels in leprosy patients from North Indian population. PLoS Negl Trop Dis. 2018 Nov

    27;12(11):e0006823.

    26. Turankar RP, Lavania Mallika, Singh Itu, Ahuja Madhvi, Pathak Vinay Kumar, Singh Vikram, Darlong J, Karthikeyan G, Sengupta Utpal. Relapse and Drug Resistance in Leprosy: Present Scenario and Critical Issues. Ind J Leprosy,2018;90:79-93.

    27. Turankar Ravindra P, Lavania Mallika, Singh Itu, Singh Vikram, Ahuja Madhvi, Pathak Vinay Kumar, Jakhmola Prashant, Das Loretta, Darlong Joydeepa, Hembrom Ujjwal. Paucibacillary Leprosy: Reappraisal using Ziehl-Neelsen staining of slit skin smears and 16S rRNA Real Time Polymerase Chain Reaction of nasal swabs. Leprosy Review,2018; 89:272-279

    28. Lavania M, Hena A, Reja H, Nigam A, Biswas NK, Singh I, Turankar RP, Gupta U, Kumar S, Rewaria L, Patra PK, Sengupta U, Bhattacharya B. Mutation at codon 442 in the rpoB gene of Mycobacterium leprae does not confer resistance to rifampicin. Lepr Rev. 2016 Mar;87(1):93-100.

    29. Turankar RP, Lavania M, Singh M, Sengupta U, Siva Sai K, Jadhav RS. Presence of viable Mycobacterium leprae in environmental specimens around houses of leprosy patients. Indian J Med Microbiol. 2016 Jul-Sep;34(3):315-21.

    30. Singh I, Lavania M, Nigam A, Turankar RP, Ahuja M, John AS, Sengupta U. Symposium on emerging needs in leprosy research in the post elimination era: The Leprosy Mission Trust India. Lepr Rev. 2016 Mar;87(1):132-43.

    31. Nigam, Astha; Lavania, Mallika; Singh, Itu; Turankar, Ravindra P. In silico analysis of novel mutations determined within RRDR region of rpoB gene of M. leprae: A possible cause of Rifampicin resistance among leprosy patients. International OPEN ACCESS Journal Of Modern Engineering Research, 2016;6: 27-35

    32. Vedithi SC, Lavania M, Kumar M, Kaur P, Turankar RP, Singh I, Nigam A, Sengupta U. A report of rifampin-resistant leprosy from northern and eastern India: identification and in silico analysis of molecular interactions. Med Microbiol Immunol. 2015 Apr;204(2):193-203

    33. Turankar RP, Pandey S, Lavania M, Singh I, Nigam A, Darlong J, Darlong F, Sengupta U. Comparative evaluation of PCR amplification of RLEP, 16S rRNA, rpoT and Sod A gene targets for detection of M. leprae DNA from clinical and environmental samples. Int J Mycobacteriol. 2015 Mar;4(1):54-9.

    34. Hasanoor Reja AH, Biswas N, Biswas S, Lavania M, Chaitanya VS, Banerjee S, Maha Patra PS, Gupta UD, Patra PK, Sengupta U, Bhattacharya B. Report of rpoB mutation in clinically suspected cases of drug resistant leprosy: a study from Eastern India. Indian J Dermatol Venereol Leprol. 2015 Mar-Apr;81(2):155-61.

    35. Lavania M, Nigam A, Turankar RP, Singh I, Gupta P, Kumar S, Sengupta U, John AS. Emergence of primary drug resistance to rifampicin in Mycobacterium leprae strains from leprosy patients in India. Clin Microbiol Infect. 2015 Dec;21(12):e85-6.

    36. Lavania M, Jadhav R, Turankar RP, Singh I, Nigam A, Sengupta U. Genotyping of Mycobacterium leprae strains from a region of high endemic leprosy prevalence in India. Infect Genet Evol. 2015 Dec;36:256-261.

    37. Nigam, Astha; Singh, Itu; Turankar, Ravindra P; Lavania, Mallika; Sengupta, Utpal. Alpha 1 Acid Glycoprotein: Increased Serum and Localized mRNA Expression as a Monitor for Reactions in Leprosy. 2015

    38. Turankar RP, Lavania M, Chaitanya VS, Sengupta U, Darlong J, Darlong F, Siva Sai KS, Jadhav RS. Single nucleotide polymorphism-based molecular typing of M. leprae from multicase families of leprosy patients and their surroundings to understand the transmission of leprosy. Clin Microbiol Infect. 2014 Mar;20(3):O142-9.

    39. Chaitanya VS, Jadhav RS, Lavania M, Singh M, Valluri V, Sengupta U. Interleukin-17F single-nucleotide polymorphism (7488T>C) and its association with susceptibility to leprosy. Int J Immunogenet. 2014 Apr;41(2):131-7

    40. Lavania M, Turankar R, Singh I, Nigam A, Sengupta U. Detection of Mycobacterium gilvum first time from the bathing water of leprosy patient from Purulia, West Bengal. Int J Mycobacteriol. 2014 Dec;3(4):286-9.

    41. Lavania M, Jadhav RS, Chaitanya VS, Turankar R, Selvasekhar A, Das L, Darlong F, Hambroom UK, Kumar S, Sengupta U. Drug resistance patterns in Mycobacterium leprae isolates from relapsed leprosy patients attending The Leprosy Mission (TLM) Hospitals in India. Lepr Rev. 2014 Sep;85(3):177-85.

    42. Lavania M, Turankar RP, Karri S, Chaitanya VS, Sengupta U, Jadhav RS. Cohort study of the seasonal effect on nasal carriage and the presence of Mycobacterium leprae in an endemic area in the general population. Clin Microbiol Infect. 2013 Oct;19(10):970-4.

    43. Lavania M, Jadhav RS, Turankar RP, Chaitanya VS, Singh M, Sengupta U. Single nucleotide polymorphisms typing of Mycobacterium leprae reveals focal transmission of leprosy in high endemic regions of India. Clin Microbiol Infect. 2013 Nov;19(11):1058-62.

    44. Chaitanya VS, Lavania M, Nigam A, Turankar RP, Singh I, Horo I, Sengupta U, Jadhav RS. Cortisol and proinflammatory cytokine profiles in type 1 (reversal) reactions of leprosy. Immunol Lett. 2013 Nov-Dec;156(1-2):159-67

    45. Chaitanya S, Lavania M, Turankar RP, Karri SR, Sengupta U. Increased serum circulatory levels of interleukin 17F in type 1 reactions of leprosy. J Clin Immunol. 2012 Dec;32(6):1415-20.

    46. Turankar RP, Lavania M, Singh M, Siva Sai KS, Jadhav RS. Dynamics of Mycobacterium leprae transmission in environmental context: deciphering the role of environment as a potential reservoir. Infect Genet Evol. 2012 Jan;12(1):121-6.

    47. Gupta AK, Katoch VM, Chauhan DS, Lavania M. Potential of Mycobacterium vanbaalenii as a model organism to study drug transporters of Mycobacterium tuberculosis, Mycobacterium marinum and Mycobacterium ulcerans: homology analysis of M. tuberculosis drug transporters among mycobacterial species. Infect Genet Evol. 2012 Jun;12(4):853-6.

    48. Lavania M, Katoch K, Sharma R, Sharma P, Das R, Gupta AK, Chauhan DS, Katoch VM. Molecular typing of Mycobacterium leprae strains from northern India using short tandem repeats. Indian J Med Res. 2011 Jun;133(6):618-26.

    49. Gupta AK, Reddy VP, Lavania M, Chauhan DS, Venkatesan K, Sharma VD, Tyagi AK, Katoch VM. jefA (Rv2459), a drug efflux gene in Mycobacterium tuberculosis confers resistance to isoniazid & ethambutol. Indian J Med Res. 2010 Aug;132:176-88.

    50. Narang R, Narang P, Jain AP, Mendiratta DK, Joshi R, Lavania M, Das R, Katoch VM. Disseminated disease caused by Mycobacterium simiae in AIDS patients: a report of three cases. Clin Microbiol Infect. 2010 Jul;16(7):912-4.

    51. Parashar D, Das R, Chauhan DS, Sharma VD, Lavania M, Yadav VS, Chauhan SV, Katoch VM. Identification of environmental mycobacteria isolated from Agra, north India by conventional & molecular approaches. Indian J Med Res. 2009 Apr;129(4):424-31.

    52. Lavania M, Lal R, Joseph G, Darlong J, Abraham S, Nanda NK, Jadhav RS. Genotypic analysis of Mycobacterium leprae strains from different regions of India on the basis of rpoT. Indian J Lepr. 2009 Jul-Sep;81(3):119-24.

    53. Lavania M, Katoch K, Katoch VM, Gupta AK, Chauhan DS, Sharma R, Gandhi R, Chauhan V, Bansal G, Sachan P, Sachan S, Yadav VS, Jadhav R. Detection of viable Mycobacterium leprae in soil samples: insights into possible sources of transmission of leprosy. Infect Genet Evol. 2008 Sep;8(5):627-31.

    54. Sharma P, Chauhan DS, Upadhyay P, Faujdar J, Lavania M, Sachan S, Katoch K, Katoch VM. Molecular typing of Mycobacterium tuberculosis isolates from a rural area of Kanpur by spoligotyping and mycobacterial interspersed repetitive units (MIRUs) typing. Infect Genet Evol. 2008 Sep;8(5):621-6.

    55. Katoch K, Singh P, Adhikari T, Benara SK, Singh HB, Chauhan DS, Sharma VD, Lavania M, Sachan AS, Katoch VM. Potential of Mw as a prophylactic vaccine against pulmonary tuberculosis. Vaccine. 2008 Feb 26;26(9):1228-34

    56. Sharma R, Lavania M, Katoch K, Chauhan DS, Gupta AK, Gupta UD, Yadav VS, Katoch VM. Development and evaluation of real-time RT-PCR assay for quantitative estimation of viable Mycobacterium leprae in clinical samples. Indian J Lepr. 2008 Oct-Dec;80(4):315-21.

    57. Lavania M, Katoch K, Parashar D, Sharma P, Das R, Chauhan DS, Sharma VD, Katoch VM. Predominance of Mycobacterium fortuitum-chelonae complex in Ghatampur field area, endemic for leprosy. Indian J Lepr. 2008 Oct-Dec;80(4):323-30.

    58. Katoch VM, Lavania M, Chauhan DS, Sharma R, Hirawati, Katoch K. Recent advances in molecular biology of leprosy. Indian J Lepr. 2007 Apr-Sep;79(2-3):151-66.

    59. Lavania M, Katoch K, Singh H, Das R, Gupta AK, Sharma R, Chauhan DS, Sharma VD, Sachan P, Sachan S, Katoch VM. Predominance of three copies of tandem repeats in rpoT gene of Mycobacterium leprae from Northern India. Infect Genet Evol. 2007 Sep;7(5):627-31.

    60. Katoch, Vishwa Mohan; Lavania, Mallika; Chauhan, Devcndra Singh; Gupta, Umesh Dutt; Environmental mycobacteria: Friends and foes. Environmental Biology and Conservation, 2007; 20:87-100.

    61. Lavania M, Katoch K, Sachan P, Dubey A, Kapoor S, Kashyap M, Chauhan DS, Singh HB, Sharma VD, Jadhav RS, Katoch VM. Detection of Mycobacterium leprae DNA from soil samples by PCR targeting RLEP sequences. J Commun Dis. 2006 Mar;38(3):269-73.

    62. Parashar D, Srivastava RK, Chauhan DS, Sharma VD, Singh M, Lavania M, Chauhan A, Bhatia AK, Katoch VM. Characterization of mycobacteria isolated from bovines by PRA-targetting hsp 65 gene region. J Commun Dis. 2006 Mar;38(3):263-8

    63. Lavania M, Katoch VM, Singh HB, Das R, Sharma VD, Chauhan DS, Natrajan M, Katoch K. Genetic polymorphism among Mycobacterium leprae strains from northern India, by using TTC repeats. Indian J Lepr. 2005 Jan-Mar;77(1):60-5.

    64. Singh HB, Katoch VM, Natrajan M, Sharma VD, Chauhan DS, Lavania M, Sharma P, Sharma M, Katoch K, Benara S, Singh P. Improved protocol for PCR detection of Mycobacterium leprae in buffered formalin-fixed skin biopsies. Int J Lepr Other Mycobact Dis. 2004 Jun;72(2):175-8.

    65. Sharma, M; Lavania, M; Sharma, P; Mohanty, KK; Katoch, K; Sengupta, U; Katoch, VM. Analysis of immune status of leprosy patients of Ghatampur field area after completion of chemotherapy by using immunological markers. Journal of Immunology and Immunopathology,2004;6 supp1: 141-142.

Chapters in Books:
  • 1. UD Gupta & Mallika Lavania. Non-tuberculous mycobacteria. In: Medical Biotechnology. PC Trivedi (ed.). Aavishkar Publishers and Distributors, Jaipur, India. Pp 51-61.
    2. UD Gupta & Mallika Lavania. Use of Real Time PCR in clinical microbiology. In: Medical Biotechnology. PC Trivedi (ed.). Aavishkar Publishers and Distributors, Jaipur, India. Pp 109-118.
    3. Mallika Lavania and U Sengupta. Drug Resistance in Leprosy (2020). In: Jopling Handbook on Leprosy Published. Sixth Edition. CBS Publishers & Distributors, Delhi. Pp 228-236
    4. RP Turankar, Itu Singh, Mallika Lavania, U Sengupta (2022). Advances in investigations for diagnosis of leprosy and drug resistance. In: IADVL Textbook of Dermatology Fifth edition. Bhalani Publishers, Mumbai. Pp 3907-3919.

 

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