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director.niv@icmr.gov.in

Dr. Alagarasu Kalichamy

HomeDr. Alagarasu Kalichamy
HomeDr. Alagarasu Kalichamy
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Dr. Alagarasu Kalichamy

Designation: Scientist E

Division: Dengue and Chikungunya Group

Educational qualifications: M.Sc., Ph.D

Date of joining ICMR-NIV: :16th Feb 2009

  • Contact: +91-26006256
  • Email: alagarasu.k@gov.in; alagarasu@gmail.com
  • Office: Indian Council of Medical Research-National Institute of Virology Pune Maharashtra - 411001

 

Research Interests:

  • Molecular epidemiology
  • Epidemiology
  • Immunology
  • mmunology
  • Diagnostics of vector borne viral diseases

 

Awards/Honours:

  • ACHIEVER OF THE YEAR” for the year 2019 from NIV research foundation
  • Prof. B.K. Aikat Oration award for the contributions in the field of tropical diseases for the year 2018 from Indian Council of Medical Research, Department of health Research, Government of India
  • Sentinels of Science Award 2016 by Publons
  • Rapid Grant for Young Investigators (RGYI) from Department of Biotechnology, Government of India (2009-2012)
  • Grant under Young Scientist Scheme from Science and Engineering Research Board, Department of Science and Technology, Government of India (2015-2017)
  • Global Health Travel Award for attending Keystone Symposia on “Hemorrhagic Fever Viruses” held at Santa Fe, New Mexico USA December 2016

 

ORCID ID: 0000-0003-1401-8589

Researcher ID: C-4879-2017

Google Scholar Profile Link

 

List of Publications
  • ◆ Thomas N, Patil P, Sharma A, Kumar S, Singh VK, Alagarasu K, Parashar D, Tapryal S. Studies on the antiviral activity of chebulinic acid against dengue and chikungunya viruses and in silico investigation of its mechanism of inhibition. Sci Rep. 2022 Jun 21;12(1):10397. 
  • ◆ Tomar SJ, Alagarasu K@, More A, Nadkarni M, Bachal R, Bote M, Patil J, Venkatesh V, Parashar D, Tandale BV. Decadal Change in Seroprevalence of Chikungunya Virus Infection in Pune City, India. Viruses. 2022 May 7;14(5):998. 
  • ◆ Alagarasu K, Patil P, Kaushik M, Chowdhury D, Joshi RK, Hegde HV, Kakade MB, Hoti SL, Cherian S, Parashar D. In Vitro Antiviral Activity of Potential Medicinal Plant Extracts Against Dengue and Chikungunya Viruses. Front Cell Infect Microbiol. 2022 Apr 7;12:866452.
  • ◆ Alagarasu K, Kaushal H, Shinde P, Kakade M, Chaudhary U, Padbidri V, Sangle SA, Salvi S, Bavdekar AR, D'costa P, Choudhary L. TNFA and IL10 Polymorphisms and IL-6 and IL-10 Levels Influence Disease Severity in Influenza A(H1N1)pdm09 Virus Infected Patients. Genes (Basel). 2021 Nov 28;12(12):1914. 
  • ◆ Alagarasu K*, Patil JA, Kakade MB, More AM, Yogesh B, Newase P, Jadhav SM, Parashar D, Kaur H, Gupta N, Vijay N, Narayan J, Shah PS; VRDL Team. Serotype and genotype diversity of dengue viruses circulating in India: a multi-centre retrospective study involving the Virus Research Diagnostic Laboratory Network in 2018. Int J Infect Dis. 2021 Oct;111:242-252.
  • ◆ Alagarasu K*. Immunomodulatory effect of vitamin D on immune response to dengue virus infection. Vitam Horm. 2021;117:239-252. 
  • ◆ Alagarasu K*, Patil JA, Kakade MB, More AM, Yogesh B, Newase P, et al. Serotype and genotype diversity of dengue viruses circulating in India: a multi-centre retrospective study involving the Virus Research Diagnostic Laboratory Network in 2018. Int J Infect Dis. 2021 Oct;111:242–52
  • ◆ Deval H, Alagarasu K#, Srivastava N, Bachal R, Mittal M, Agrawal A, et al. Association of single nucleotide polymorphisms in the CD209, MMP9, TNFA and IFNG genes with susceptibility to Japanese encephalitis in children from North India. Gene. 2021 Sep 14;808:145962.
  • ◆ Alagarasu K*. Immunomodulatory effect of vitamin D on immune response to dengue virus infection. Vitam Horm. 2021;117:239–52.
  • ◆ Alagarasu K*, Kakade MB, Bachal RV, Bote M, Parashar D, Shah PS. Use of whole blood over plasma enhances the detection of dengue virus RNA: possible utility in dengue vaccine trials. Arch Virol. 2021 Feb;166(2):587–91.
  • ◆ Panda K, Alagarasu K#, Parashar D. Oligonucleotide-Based Approaches to Inhibit Dengue Virus Replication. Molecules. 2021 Feb 11;26(4):956.
  • ◆ Panda K, Alagarasu K@, Patil P, Agrawal M, More A, Kumar NV, et al. In Vitro Antiviral Activity of α-Mangostin against Dengue Virus Serotype-2 (DENV-2). Molecules. 2021 May 19;26(10):3016.
  • ◆ Patil P, Agrawal M, Almelkar S, Jeengar MK, More A, Alagarasu K, et al. In vitro and in vivo studies reveal α-Mangostin, a xanthonoid from Garcinia mangostana, as a promising natural antiviral compound against chikungunya virus. Virol J. 2021 Feb 28;18(1):47.
  • ◆ Panda K, Alagarasu K, Cherian SS, Parashar D. Prediction of potential small interfering RNA molecules for silencing of the spike gene of SARS-CoV-2. Indian J Med Res.  Jan & Feb;153(1 & 2):182-189.
  • ◆ Newase P, More A, Patil J, Patil P, Jadhav S, Alagarasu K, et al. Chikungunya phylogeography reveals persistent global transmissions of the Indian Ocean Lineage from India in association with mutational fitness. Infect Genet Evol. 2020 Aug;82:104289.
  • ◆  Alagarasu K, Potdar VA, Vipat V, Hundekar S, Gunjikar R, Choudhary ML, et al. Utility of a modified heat inactivation method for direct detection of SARS-CoV-2 by RT-qPCR in viral transport medium bypassing RNA extraction: A preliminary study. Indian J Med Res. 2020 Aug;152(1 & 2):108–10.
  • ◆ Kakade MB, Shrivastava N, Patil JA, Parashar D, Shah PS, Alagarasu K*. Clinical evaluation of an in-house-developed real-time RT-PCR assay for serotyping of dengue virus. Arch Virol. 2020 Oct;165(10):2311–5.
  • ◆ Rajesh NT, Alagarasu K*, Patil JA, Bharathi E, More A, Kakade MB, et al. Serotype-specific differences in the laboratory parameters among hospitalized children with dengue and genetic diversity of dengue viruses circulating in Tamil Nadu, India during 2017. J Med Virol. 2020 Aug;92(8):1013–22.
  • ◆ Alagarasu K, Choudhary ML, Lole KS, Abraham P, Potdar V. Evaluation of RdRp & ORF-1b-nsp14-based real-time RT-PCR assays for confirmation of SARS-CoV-2 infection: An observational study. Indian J Med Res. 2020 May;151(5):483–5.
  • ◆ Alagarasu K*, Patil JA, Kakade MB, More AM, Bote M, Chowdhury D, et al. Spatio-temporal distribution analysis of circulating genotypes of dengue virus type 1 in western and southern states of India by a one-step real-time RT-PCR assay. Infect Genet Evol. 2019 Nov;75:103989.
  • ◆ Krishnakumar V, Durairajan SSK, Alagarasu K, Li M, Dash AP. Recent Updates on Mouse Models for Human Immunodeficiency, Influenza, and Dengue Viral Infections. Viruses. 2019 Mar 13;11(3):E252.
  • ◆ Deval H, Alagarasu K@, Mittal M, Srivastava N, Bachal R, Gondhalekar A, et al. Association of single nucleotide polymorphisms in TNFA and CCR5 genes with Japanese Encephalitis: A study from an endemic region of North India. J Neuroimmunol. 2019 Nov 15;336:577043.
  • ◆ Jadhav NJ, Gokhale S, Seervi M, Patil PS, Alagarasu K*. Immunomodulatory effect of 1, 25 dihydroxy vitamin D3 on the expression of RNA sensing pattern recognition receptor genes and cytokine response in dengue virus infected U937-DC-SIGN cells and THP-1 macrophages. Int Immunopharmacol. 2018 Sep;62:237–43.
  • ◆ Patil JA, Alagarasu K*, Kakade MB, More AM, Gadekar KA, Jadhav SM, et al. Emergence of dengue virus type 1 and type 3 as dominant serotypes during 2017 in Pune and Nashik regions of Maharashtra, Western India. Infect Genet Evol. 2018 Dec;66:272–83.
  • ◆ Shah PS, Alagarasu K, Karad S, Deoshatwar A, Jadhav SM, Raut T, et al. Seroprevalence and incidence of primary dengue infections among children in a rural region of Maharashtra, Western India. BMC Infect Dis. 2019 Apr 2;19(1):296.
  • ◆ Tripathy AS, Ganu MA, Sonam L, Alagarasu K, Walimbe AM, Thanapati S, et al. Association of IL1RN VNTR polymorphism with chikungunya infection: A study from Western India. J Med Virol. 2019 Nov;91(11):1901–8.
  • ◆ Choudhary ML, Alagarasu K, Chaudhary U, Kawale S, Malasane P, Gurav YK, et al. Association of Single Nucleotide Polymorphisms in TNFA and IL10 Genes with Disease Severity in Influenza A/H1N1pdm09 Virus Infections: A Study from Western India. Viral Immunol. 2018 Dec;31(10):683–8.
  • ◆ Shah PS, Deoshatwar A, Karad S, Mhaske S, Singh A, Bachal RV, et al. Seroprevalence of dengue in a rural and an urbanized village: A pilot study from rural western India. J Vector Borne Dis. 2017 Jun;54(2):172–6.
  • ◆ Alagarasu K*, Patil PS, Shil P, Seervi M, Kakade MB, Tillu H, et al. In-vitro effect of human cathelicidin antimicrobial peptide LL-37 on dengue virus type 2. Peptides. 2017 Jun;92:23–30.
  • ◆ Cecilia D, Patil JA, Kakade MB, Walimbe A, Alagarasu K, Anukumar B, et al. Emergence of the Asian genotype of DENV-1 in South India. Virology. 2017 Oct;510:40–5.
  • ◆ Amdekar S, Parashar D, Alagarasu K*. Chikungunya Virus-Induced Arthritis: Role of Host and Viral Factors in the Pathogenesis. Viral Immunol. 2017 Dec;30(10):691–702.
  • ◆ Bachal R, Alagarasu K, Singh A, Salunke A, Shah P, Cecilia D. Higher levels of dengue-virus-specific IgG and IgA during pre-defervescence associated with primary dengue hemorrhagic fever. Arch Virol. 2015 Oct;160(10):2435–43.
  • ◆ Chaaithanya IK, Muruganandam N, Surya P, Anwesh M, Alagarasu K, Vijayachari P. Association of Oligoadenylate Synthetase Gene Cluster and DC-SIGN (CD209) Gene Polymorphisms with Clinical Symptoms in Chikungunya Virus Infection. DNA Cell Biol. 2016 Jan;35(1):44–50.
  • ◆ Alagarasu K*, Walimbe AM, Jadhav SM, Deoshatwar AR. A meta-analysis of the diagnostic accuracy of dengue virus-specific IgA antibody-based tests for detection of dengue infection. Epidemiol Infect. 2016 Mar;144(4):876–86.
  • ◆ Alagarasu K. Introducing dengue vaccine: Implications for diagnosis in dengue vaccinated subjects. Vaccine. 2016 May 27;34(25):2759–61.
  • ◆ Cecilia D, Kakade M, Alagarasu K, Patil J, Salunke A, Parashar D, et al. Development of a multiplex real-time RT-PCR assay for simultaneous detection of dengue and chikungunya viruses. Arch Virol. 2015 Jan;160(1):323–7.
  • ◆ Alagarasu K*, Bachal RV, Memane RS, Shah PS, Cecilia D. Polymorphisms in RNA sensing toll like receptor genes and its association with clinical outcomes of dengue virus infection. Immunobiology. 2015 Jan;220(1):164–8.
  • ◆ Alagarasu K*, Bachal RV, Shah PS, Cecilia D. Profile of killer cell immunoglobulin-like receptor and its human leucocyte antigen ligands in dengue-infected patients from Western India. Int J Immunogenet. 2015 Dec;42(6):432–8.
  • ◆ Alagarasu K*, Bachal RV, Tillu H, Mulay AP, Kakade MB, Shah PS, et al. Association of combinations of interleukin-10 and pro-inflammatory cytokine gene polymorphisms with dengue hemorrhagic fever. Cytokine. 2015 Jul;74(1):130–6.
  • ◆ Alagarasu K*, Memane RS, Shah PS. Polymorphisms in the retinoic acid-1 like-receptor family of genes and their association with clinical outcome of dengue virus infection. Arch Virol. 2015 Jun;160(6):1555–60.
  • ◆ Alagarasu K*, Bachal RV, Damle I, Shah PS, Cecilia D. Association of FCGR2A p.R131H and CCL2 c.-2518 A>G gene variants with thrombocytopenia in patients with dengue virus infection. Hum Immunol. 2015 Nov;76(11):819–22.
  • ◆ Alagarasu K*, Damle IM, Bachal RV, Mulay AP, Shah PS, Dayaraj C. Association of promoter region polymorphisms of CD209 gene with clinical outcomes of dengue virus infection in Western India. Infect Genet Evol. 2013 Jul;17:239–42.
  • ◆ Alagarasu K*, Mulay AP, Sarikhani M, Rashmika D, Shah PS, Cecilia D. Profile of human leukocyte antigen class I alleles in patients with dengue infection from Western India. Hum Immunol. 2013 Dec;74(12):1624–8.
  • ◆ Alagarasu K*, Mulay AP, Singh R, Gavade VB, Shah PS, Cecilia D. Association of HLA-DRB1 and TNF genotypes with dengue hemorrhagic fever. Hum Immunol. 2013 May;74(5):610–7.
  • ◆ Das R, Rathod SB, Alagarasu K, Arankalle VA, Tripathy AS. Altered expressions of peripheral CD11c, CD80, CD83 markers and associations of HLA class II allele and haplotypes in self-limiting Hepatitis E infection. Hum Immunol. 2013 Mar;74(3):277–85.
  • ◆ Alagarasu K*, Honap T, Damle IM, Mulay AP, Shah PS, Cecilia D. Polymorphisms in the oligoadenylate synthetase gene cluster and its association with clinical outcomes of dengue virus infection. Infect Genet Evol. 2013 Mar;14:390–5.
  • ◆ Alagarasu K, Bachal RV, Bhagat AB, Shah PS, Dayaraj C. Elevated levels of vitamin D and deficiency of mannose binding lectin in dengue hemorrhagic fever. Virol J. 2012 May 4;9:86.
  • ◆ Raghavan S, Alagarasu K, Selvaraj P. Immunogenetics of HIV and HIV associated tuberculosis. Tuberculosis (Edinb). 2012 Jan;92(1):18–30.
  • ◆ Alagarasu K*, Honap T, Mulay AP, Bachal RV, Shah PS, Cecilia D. Association of vitamin D receptor gene polymorphisms with clinical outcomes of dengue virus infection. Hum Immunol. 2012 Nov;73(11):1194–9.
  • ◆ Alagarasu K, Selvaraj P, Swaminathan S, Narendran G, Narayanan PR. 5’ regulatory and 3’ untranslated region polymorphisms of vitamin D receptor gene in south Indian HIV and HIV-TB patients. J Clin Immunol. 2009 Mar;29(2):196–204.
  • ◆ Alagarasu K, Selvaraj P, Swaminathan S, Raghavan S, Narendran G, Narayanan PR. CCR2, MCP-1, SDF-1a & DC-SIGN gene polymorphisms in HIV-1 infected patients with & without tuberculosis. Indian J Med Res. 2009 Oct;130(4):444–50.
  • ◆ Alagarasu K, Selvaraj P, Swaminathan S, Raghavan S, Narendran G, Narayanan PR. Mannose binding lectin gene variants and susceptibility to tuberculosis in HIV-1 infected patients of South India. Tuberculosis (Edinb). 2007 Nov;87(6):535–43.
  • ◆ Raghavan S, Selvaraj P, Swaminathan S, Alagarasu K, Narendran G, Narayanan PR. Haplotype analysis of HLA-A, -B antigens and -DRB1 alleles in south Indian HIV-1-infected patients with and without pulmonary tuberculosis. Int J Immunogenet. 2009 Jun;36(3):129–33.
  • ◆ Selvaraj P, Alagarasu K, Singh B. Stromal cell-derived factor-1 (SDF-1/CXCL12) gene polymorphisms in pulmonary tuberculosis patients of south India. Int J Immunogenet. 2012 Feb;39(1):26–31.
  • ◆ Selvaraj P, Alagarasu K, Swaminathan S, Harishankar M, Narendran G. CD209 gene polymorphisms in South Indian HIV and HIV-TB patients. Infect Genet Evol. 2009 Mar;9(2):256–62.
  • ◆ Selvaraj P, Alagarasu K, Singh B, Afsal K. CCL5 (RANTES) gene polymorphisms in pulmonary tuberculosis patients of south India. Int J Immunogenet. 2011 Oct;38(5):397–402.
  • ◆ Selvaraj P, Prabhu Anand S, Harishankar M, Alagarasu K. Plasma 1,25 dihydroxy vitamin D3 level and expression of vitamin d receptor and cathelicidin in pulmonary tuberculosis. J Clin Immunol. 2009 Jul;29(4):470–8.
  • ◆ Selvaraj P, Raghavan S, Swaminathan S, Alagarasu K, Narendran G, Narayanan PR. HLA-DQB1 and -DPB1 allele profile in HIV infected patients with and without pulmonary tuberculosis of south India. Infect Genet Evol. 2008 Sep;8(5):664–71.
  • ◆ Selvaraj P, Alagarasu K, Harishankar M, Vidyarani M, Nisha Rajeswari D, Narayanan PR. Cytokine gene polymorphisms and cytokine levels in pulmonary tuberculosis. Cytokine. 2008 Jul;43(1):26–33.
  • ◆ Selvaraj P, Vidyarani M, Alagarasu K, Prabhu Anand S, Narayanan PR. Regulatory role of promoter and 3’ UTR variants of vitamin D receptor gene on cytokine response in pulmonary tuberculosis. J Clin Immunol. 2008 Jul;28(4):306–13.
  • ◆ Selvaraj P, Alagarasu K, Harishankar M, Vidyarani M, Narayanan PR. Regulatory region polymorphisms of vitamin D receptor gene in pulmonary tuberculosis patients and normal healthy subjects of south India. Int J Immunogenet. 2008 Jun;35(3):251–4.
  • ◆ Selvaraj P, Jawahar MS, Rajeswari DN, Alagarasu K, Vidyarani M, Narayanan PR. Role of mannose binding lectin gene variants on its protein levels and macrophage phagocytosis with live Mycobacterium tuberculosis in pulmonary tuberculosis. FEMS Immunol Med Microbiol. 2006 Apr;46(3):433–7.
  • ◆ Selvaraj P, Swaminathan S, Alagarasu K, Raghavan S, Narendran G, Narayanan P. Association of human leukocyte antigen-A11 with resistance and B40 and DR2 with susceptibility to HIV-1 infection in south India. J Acquir Immune Defic Syndr. 2006 Dec 1;43(4):497–9.

 

*Corresponding Author

# Equal corresponding Author

@ Equal First Author

 

 

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