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Dr. Gururaj Rao Deshpande

HomeDr. Gururaj Rao Deshpande
HomeDr. Gururaj Rao Deshpande
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Dr. Gururaj Rao Deshpande

Designation: Scientist ‘C’ (Non-Medical)

Division: Diagnostic Virology Group (DVG)

Educational qualifications: M.Sc. PhD (Biotechnology)

Date of joining ICMR-NIV: 1st August 2019

  • Contact: 020 - 26006835
  • Email: gndeshpande@gmail.com, deshpande.gn@icmr.gov.in
  • Office: ICMR-National Institute of Virology, Diagnostic Virology Group, MCC 130/1 Sus Road, Pashan, Pune, Maharashtra 411021

 

Research Interests:

  • Serodiagnostic assay development
  • Antibody responses: Viral infections and vaccination
  • Laboratory Quality Assurance /Quality Control and capacity building
  • Translational research

 

Awards/Honours:

  • Best E-poster Award: for poster entitled as: Development of anti-SARS-CoV-2 mouse monoclonal antibodies of diagnostic and therapeutic potential” In Virocon-2021, held from March 26 to 28, 2022.

 

ORCID ID:0000-0001-6946-4469

Researcher ID:J-7380-2018

Google Scholar Profile Link

 

List of Publications
  • 1. Deshpande GR, Yadav PD, Abraham P, Nyayanit DA, Sapkal GN,Booster dose of the inactivated COVID-19 vaccine BBV152 (Covaxin) enhances the neutralizing antibody response against alpha, Beta, Delta and omicron variants of concern. J Travel Med. 2022 Mar 24:taac039. doi: 10.1093/jtm/taac039. Epub ahead of print. PMID: 35325176.

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    2. Sapkal G, Deshpande GR, Tilekar B, Yadav P, Abraham P, Salunke A, Patil C, Deshpande K, Patil R, Pawar N, Joshi A, Vaidya A, Shivankar A. Antibody responses to Sputnik Vaccination in naïve and COVID 19-recovered vaccine recipients, India. J Travel Med. 2022 Mar 24: taac040. doi: 10.1093/jtm/taac040. Epub ahead of print. PMID: 35325194; PMCID: PMC8992299.

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    3. Yadav, P. D., Sapkal, G. N., Abraham, P., Ella, R., Deshpande, G., Patil, D. Y., Nyayanit, D. A., Gupta, N., Sahay, R. R., Shete, A. M., Panda, S., Bhargava, B., & Mohan, V. K. (2022). Neutralization of Variant Under Investigation B.1.617.1 With Sera of BBV152 Vaccinees. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 74(2), 366–368. https://doi.org/10.1093/cid/ciab411

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    4. Sahay RR, Patil DY, Sapkal GN, Deshpande GR, Shete AM, Nyayanit DA, Kumar S, Yadav PD. SARS-CoV-2 Delta and delta derivatives impact on neutralization of Covishield recipient sera. J Infect. 2022 Feb 19:S0163-4453(22)00082-2. doi: 10.1016/j.jinf.2022.02.018. Epub ahead of print. PMID: 35192896; PMCID: PMC8857767.

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    5. Yadav PD, Sapkal GN, Sahay RR, Patil DY, Deshpande GR, Jain R, Nyayanit DA, Shete AM, Suryawanshi A, Nandapurkar A, Gurav YK, Abraham P. Elevated neutralization of Omicron with sera of COVID-19 recovered and breakthrough cases vaccinated with Covaxin than two dose naïve vaccinees. J Infect. 2022 Mar 19:S0163-4453(22)00170-0. doi: 10.1016/j.jinf.2022.03.016.

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    6. Pragya D. Yadav#*, Gajanan N. Sapkal#, Rima R. Sahay#, Varsha A. Potdar, Gururaj R Pradeep Awate, Bharti Malhotra, Priya Abraham. Substantial immune response in Omicron infected breakthrough and unvaccinated individuals against SARS-CoV-2 variants of concerns, Journal of Infection

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    7. Gurav, Y. K., Alagarasu, K., Yadav, P. D., Sapkal, G., Gokhale, M., Parashar, D., Jadhav, U., Bote, M., Kakade, M., Nyayanit, D., Kumar, A., Deshpande, G. R., Cherian, S., Awate, P. S., & Abraham, P. (2022). First case of Zika virus infection during an outbreak of chikungunya in a rural region of Maharashtra state, India. Transactions of the Royal Society of Tropical Medicine and Hygiene, trac022. Advance online publication. https://doi.org/10.1093/trstmh/trac022

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    8. Ojas Kaduskar, Yogesh Gurav, Ketki Deshpande, Gururaj Rao Deshpande, Pragya D. Yadav, Aparna Rakhe, Bipin Tilekar, Prasad Gomade, Asha Salunke, Chetan Patil, Varsha Dange, Pavan Salvi, Sudhir Patsuthe, Priya Abraham, Gajanan Sapkal* Understanding dynamics of IgM and IgG antibody in COVID-19 positive patients (IJMR)

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    9. Mohandas S, Yadav PD, Sapkal G, Shete AM, Deshpande G, Nyayanit DA, Patil D, Kadam M, Kumar A, Mote C, Jain R. Pathogenicity of SARS-CoV-2 Omicron (R346K) variant in Syrian hamsters and its cross-neutralization with different variants of concern. EBioMedicine. 2022 Apr 8; 79:103997. doi: 10.1016/j.ebiom.2022.103997. Epub ahead of print. PMID: 35405385; PMCID: PMC8993158.

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    10. Deshpande, K., Pt, U., Kaduskar, O., Vijay, N., Rakhe, A., Vidhate, S., Khutwad, K., Deshpande, G. R., Tilekar, B., Saka, S., Gadekar, K., Patil, R., Yadav, P., Potdar, V., Gurav, Y., Gupta, P., Kaur, H., Narayan, J., Sapkal, G., & Abraham, P. (2021). Performance assessment of seven SARS-CoV-2 IgG enzyme-linked immunosorbent assays. Journal of medical virology, 93(12), 6696–6702. https://doi.org/10.1002/jmv.27251

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    11. Deshpande, G. R., Bhukya, P. L., Yadav, P. D., Salunke, A., Patil, C., Tilekar, B. N., Rakhe, A., Srivastava, R., Gurav, Y. K., Potdar, V., Abraham, P., & Sapkal GN*. (2021). Comparison of neutralizing antibody response in first and second waves of SARS CoV-2 pandemic in India. Journal of travel medicine, taab196.

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    12. Bhatnagar, Tarun, Gururaj Rao Deshpande, Bharti Malhotra, Padinjaremattathil Thankappan Ullas, Rutuja Dhawde, Sharada Sharma, Mukesh Mittal, Sapkal GN et al. "No evidence of recent Zika virus transmission among the cohort of pregnant women after the 2018 outbreak in Jaipur city, Rajasthan, India, 2019-20." Journal of Clinical Virology Plus (2021): 100031

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    13. Hasan AZ, Kumar MS, Prosperi C, Thangaraj JWV, Sabarinathan R, Kumar S, Duraiswamy A, Kaduskar O, Bhatt V, Deshpande GR, Ullas PT, Sapkal GN et al. Implementing Serosurveys in India: Experiences, Lessons Learned, and Recommendations. Am J Trop Med Hyg. 2021 Oct 4: tpmd210401. doi: 10.4269/ajtmh.21-0401. Epub ahead of print. PMID: 34607310.

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    14. Prosperi, C., Kaduskar, O., Bhatt, V., Hasan, A. Z., Vivian Thangaraj, J. W., Kumar, M. S., Sabarinathan, R., Kumar, S., Duraiswamy, A., Deshpande, G. R., Padinjaremattathil Thankappan, U., Chauhan, S. L., Kulkarni, R. N., Bansal, A. K., Chaaithanya, I. K., Salvi, N. R., Sharma, S., Moss, W. J., Sangal, L., Gupta, N., … Hayford, K. (2021). Diagnostic Accuracy of Dried Blood Spots Collected on HemaSpot HF Devices Compared to Venous Blood Specimens To Estimate Measles and Rubella Seroprevalence. mSphere, 6(4), e0133020. https://doi.org/10.1128/mSphere.01330-20

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    15. Kaduskar O, Bhatt V, Prosperi C, Hayford K, Hasan AZ, Deshpande GR, Tilekar B, Vivian Thangaraj JW, Kumar MS, Gupta N, Murhekar MV, Moss WJ, Mehendale SM, Sangal L, Sapkal GN*. Optimization and Stability Testing of Four Commercially Available Dried Blood Spot Devices for Estimating Measles and Rubella IgG Antibodies. mSphere. 2021 Aug 25;6(4):e0049021. doi: 10.1128/mSphere.00490-21. Epub 2021 Jul 14. PMID: 34259563; PMCID: PMC8386427

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    16. Sapkal, G. N., Yadav, P. D., Ella, R., Deshpande, G. R., Sahay, R. R., Gupta, N., Vadrevu, K. M., Abraham, P., Panda, S., & Bhargava, B. (2021). Inactivated COVID-19 vaccine BBV152/COVAXIN effectively neutralizes recently emerged B.1.1.7 variant of SARS-CoV-2. Journal of travel medicine, 28(4), taab051. https://doi.org/10.1093/jtm/taab051

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    17. Mohandas, S., Yadav, P. D., Shete-Aich, A., Abraham, P., Vadrevu, K. M., Sapkal, G., Mote, C., Nyayanit, D., Gupta, N., Srinivas, V. K., Kadam, M., Kumar, A., Majumdar, T., Jain, R., Deshpande, G., Patil, S., Sarkale, P., Patil, D., Ella, R., Prasad, S. D., … Bhargava, B. (2021). Immunogenicity and protective efficacy of BBV152, whole virion inactivated SARS- CoV-2 vaccine candidates in the Syrian hamster model. iScience, 24(2), 102054. https://doi.org/10.1016/j.isci.2021.102054

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    18. Yadav, P. D., Ella, R., Kumar, S., Patil, D. R., Mohandas, S., Shete, A. M., Vadrevu, K. M., Bhati, G., Sapkal, G., Kaushal, H., Patil, S., Jain, R., Deshpande, G., Gupta, N., Agarwal, K., Gokhale, M., Mathapati, B., Metkari, S., Mote, C., Nyayanit, D., … Bhargava, B. (2021). Immunogenicity and protective efficacy of inactivated SARS-CoV-2 vaccine candidate, BBV152 in rhesus macaques. Nature communications, 12(1), 1386. https://doi.org/10.1038/s41467-021-21639-w

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    19. Ganneru, B., Jogdand, H., Daram, V. K., Das, D., Molugu, N. R., Prasad, S. D., Kannappa, S. V., Ella, K. M., Ravikrishnan, R., Awasthi, A., Jose, J., Rao, P., Kumar, D., Ella, R., Abraham, P., Yadav, P. D., Sapkal, G. N., Shete-Aich, A., Desphande, G., Mohandas, S., … Vadrevu, K. M. (2021). Th1 skewed immune response of whole virion inactivated SARS CoV 2 vaccine and its safety evaluation. iScience, 24(4), 102298. https://doi.org/10.1016/j.isci.2021.102298

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    20. Deshpande, G. R., Kaduskar, O., Deshpande, K., Bhatt, V., Yadav, P., Gurav, Y., Potdar, V., Khutwad, K., Vidhate, S., Salunke, A., Patil, C., Shingade, S., Jarande, K., Tilekar, B., Salvi, P., Patsuthe, S., Dange, V., Kumar, S., Gurav, S., Chate, S., Sapkal, G. (2021). Longitudinal clinico-serological analysis of anti-nucleocapsid and anti-receptor binding domain of spike protein antibodies against SARS-CoV-2. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 112, 103–110. https://doi.org/10.1016/j.ijid.2021.09.024

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    21. Kant, R., Dwivedi, G., Zaman, K., Sahay, R. R., Sapkal, G., Kaushal, H., Nyayanit, D. A., Yadav, P. D., Deshpande, G., Singh, R., Chaowdhary, S., Gupta, N., Kumar, S., Abraham, P., Panda, S., & Bhargava, B. (2021). Immunogenicity and safety of a heterologous prime-boost COVID-19 vaccine schedule: ChAdOx1 vaccine Covishield followed by BBV152 Covaxin. Journal of travel medicine28(8), taab166. https://doi.org/10.1093/jtm/taab166

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    22. Munivenkatappa A, Sahay RR, Deshpande GR, Patil DY, Shete AM, Sapkal GN et al. A case with SARS-CoV-2 reinfection from India. Indian J Med Microbiol. 2021 Nov 15:S0255-0857(21)04647-8. doi: 10.1016/j.ijmmb.2021.09.010. Epub ahead of print. PMID: 34789389; PMCID: PMC8590946.

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    23. Yadav PD, Sapkal GN#, Ella R, Sahay RR, Nyayanit DA, Patil DY, Deshpande G, Shete AM, Gupta N, Mohan VK, Abraham P, Panda S, Bhargava B. Neutralization of Beta and Delta variant with sera of COVID-19 recovered cases and vaccinees of inactivated COVID-19 vaccine BBV152/Covaxin. J Travel Med. 2021 Oct 11;28(7): taab104. doi: 10.1093/jtm/taab104. PMID: 34230972; PMCID: PMC8344909.

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    24. Yadav, P. D., Sapkal, G. N., Abraham, P., Deshpande, G., Nyayanit, D. A., Patil, D. Y., Gupta, N., Sahay, R. R., Shete, A. M., Kumar, S., Panda, S., & Bhargava, B. (2022). Neutralization Potential of Covishield Vaccinated Individuals Sera Against B.1.617.1. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 74(3), 558–559. https://doi.org/10.1093/cid/ciab483

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    25. Sapkal, G. N., Yadav, P. D., Sahay, R. R., Deshpande, G., Gupta, N., Nyayanit, D. A., Patil, D. Y., Shete, A. M., Kumar, S., Abraham, P., Panda, S., & Bhargava, B. (2021). Neutralization of Delta variant with sera of Covishield™ vaccinees and COVID-19-recovered vaccinated individuals. Journal of travel medicine, 28(7), taab119. https://doi.org/10.1093/jtm/taab119

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    26. Yadav, P. D., Sahay, R. R., Sapkal, G., Nyayanit, D., Shete, A. M., Deshpande, G., Patil, D. Y., Gupta, N., Kumar, S., Abraham, P., Panda, S., & Bhargava, B. (2021). Comparable neutralization of SARS-CoV-2 Delta AY.1 and Delta with individuals sera vaccinated with BBV152. Journal of travel medicine, 28(8), taab154. https://doi.org/10.1093/jtm/taab154

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    27. Deshpande GR, Sapkal GN*, Tilekar BN, Yadav PD, Gurav Y, Gaikwad S, Kaushal H, Deshpande KS, Kaduskar O, Sarkale P, Baradkar S, Suryawanshi A, Lakra R, Sugunan AP, Balakrishnan A, Abraham P, Salve P. Neutralizing antibody responses to SARS-CoV-2 in COVID-19 patients. Indian J Med Res. 2020 Jul & Aug; 152(1 & 2):82-87. DOI:10.4103 /ijmr.IJMR_ 2382_20.  PMID: 32859866; PMCID: PMC7853248.

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    28. Sapkal, G., Shete-Aich, A., Jain, R., Yadav, P. D., Sarkale, P., Lakra, R., Baradkar, S., Deshpande, G. R., Mali, D., Tilekar, B. N., Majumdar, T., Kaushal, H., Gurav, Y., Gupta, N., Mohandas, S., Deshpande, K., Kaduskar, O., Salve, M., Patil, S., Gaikwad, S., … $COVID Support Team: Pawar S., Patshute S., Salve V., Natarajan V., Marwah V., Malhotra B., Jain A., Sathe P., More R., Khedekar R., Suryawanshi D., Kalele K., Kumar A., Upadhyaya C.P., Waghmare A., Gawande P., Gopale S., Acharya M., Holeppanavar M., Thorat S., Chopade G., Vidhate S., Khutwad K., Phagiwala D., Bhanarkar S., Rakhe A., Salvi V., Dhaigude S., Ciyona (2020). Development of indigenous IgG ELISA for the detection of anti-SARS-CoV-2 IgG. The Indian journal of medical research, 151(5), 444–449. https://doi.org/10.4103/ijmr.IJMR_2232_20

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    29. Mohandas, S., Jain, R., Yadav, P. D., Shete-Aich, A., Sarkale, P., Kadam, M., Kumar, A., Deshpande, G., Baradkar, S., Patil, S., Sapkal, G., Mali, D., Salve, M., Patil, D., Majumdar, T., Suryawanshi, A., Kaushal, H., Lakra, R., Dighe, H., Gupta, N., … Gangakhedkar, R. R. (2020). Evaluation of the susceptibility of mice & hamsters to SARS-CoV-2 infection. The Indian journal of medical research, 151(5), 479–482. https://doi.org/10.4103/ijmr.IJMR_2235_20

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    30. Mohandas S, Jain R, Yadav PD, Shete-Aich A, Sarkale P, Kadam M, Kumar A, Deshpande G, Baradkar S, Patil S, Sapkal GN, Mali D, Salve M, Patil D, Majumdar T, Suryawanshi A, Kaushal H, Lakra R, Dighe H, Gupta N, Abraham P, Gangakhedkar RR. Evaluation of the susceptibility of mice & hamsters to SARS-CoV-2 infection. Indian J Med Res. 2020 May; 151(5):479-482. DOI: 10.4103/ijmr.IJMR_2235_20. PMID: 32611917; PMCID: PMC7530454.

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    31. Sapkal GN#, Anil Yadav, Gururaj Rao Deshpande, Pragya D. Yadav, Ketki Deshpande, Darpan Phagiwala, Rajlaxmi Jain et al. "Development of equine antisera with high neutralizing activity against SARS-CoV-2." (2020).

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    32. Malhotra, B., Gupta, V., Sharma, P., Singh, R., Sharma, H., Vyas, M., Mathur, R. P., Mathur, V. K., Meena, D., Malhotra, H., Yadav, P. D., Sapkal, G., Pt, U., Rao Deshpande, G., Gunjikar, R., Shaman, H., Mourya, D. T., Gupta, N., Singh, S., Ravindran, P., … Salaria, M. (2020). Clinico-epidemiological and genomic profile of first Zika Virus outbreak in India at Jaipur city of Rajasthan state. Journal of infection and public health, 13(12), 1920–1926. https://doi.org/10.1016/j.jiph.2020.10.006

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    33. Agarwal A, Mukherjee A, Kumar G, Chatterjee P, Bhatnagar T, Malhotra P, Sapkal GN; PLACID Trial Collaborators: Deshpande G. Convalescent plasma in the management of moderate covid-19 in adults in India: open label phase II multicentre randomised controlled trial (PLACID Trial). BMJ. 2020 Oct 22;371:m3939. doi: 10.1136/bmj.m3939. Erratum in: BMJ. 2020 Nov 3;371:m4232. PMID: 33093056; PMCID: PMC7578662.

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    34. Potdar V, Cherian SS, Deshpande GR, Ullas PT, Yadav PD, Choudhary ML, Gughe R, Vipat V, Jadhav S, Patil S, Nyayanit D, Majumdar T, Walimbe A, Gaikwad S, Dighe H, Shete-Aich A, Mohandas S, Chowdhury D, Sapkal GN, Basu A, Gupta N, Gangakhedkar RR, Giri S, Dar L, Jain A, Malhotra B, Abraham P; National Influenza Centre (NIC) Team: Genomic analysis of SARS-CoV-2 strains among Indians returning from Italy, Iran & China, & Italian tourists in India. Indian J Med Res. 2020 Feb & Mar; 151(2 & 3):255-260. DOI: 10.4103/ijmr.IJMR_1058_20. PMID: 32362650; PMCID: PMC7366550.

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    35. Yadav PD, Malhotra B, Sapkal G, Nyayanit DA, Deshpande G, Gupta N, Padinjaremattathil UT, Sharma H, Sahay RR, Sharma P, Mourya DT. Zika virus outbreak in Rajasthan, India in 2018 was caused by a virus endemic to Asia. Infect Genet Evol. 2019 Apr; 69:199-202. doi: 10.1016/j.meegid.2019.01.026. Epub 2019 Jan 28. PMID: 30703541.

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    36. Viswanathan R, Bafna S, Mergu R, Deshpande G, Gunjikar R, Gaikwad S, Mullick J. Direct Saliva Real-time Polymerase Chain Reaction Assay Shows Low Birth Prevalence of Congenital Cytomegalovirus Infection in Urban Western India. Pediatr Infect Dis J. 2019 Apr;38(4):e65-e68. doi: 10.1097/INF.0000000000002094. PMID: 30882739.

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    37. Deshpande, Gururaj Rao, Bipin Tilekar, Supriya L. Hundekar, Kirtee Khutwad, Rashmi S. Gunjikar, Shankar Vidhate, and Sapkal GN*. "Molecular characterization of chikungunya virus from urbanized villages of Pune, Maharashtra, India, 2016." The Indian journal of medical research 148, no. 6 (2018): 756.

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    38. Murhekar M, Bavdekar A, Benakappa A, Santhanam S, Singh K, Verma S, Sapkal GN, Gupta N, Verghese VP, Viswanathan R, Abraham AM, Choudhary S, Deshpande GN, George S, Goyal G, Lepcha A, Mahantesh S, et al. Sentinel Surveillance for Congenital Rubella Syndrome - India, 2016-2017. MMWR Morb Mortal Wkly Rep. 2018

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    39. Narayanan P, Das A, Morineau G, Prabhakar P, Deshpande GR, Gangakhedkar R, Risbud A. An exploration of elevated HIV and STI risk among male sex workers from India. BMC Public Health. 2013 Nov 9;13:1059. doi: 10.1186/1471-2458-13-1059. PMID: 24209579; PMCID: PMC4226023.

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    40. Risbud AR, Rao G, Das A, Narayanan P, Prabhakar P. Detection of N. gonorrhoeae and C. trachomatis infection using urine sample from symptomatic high-risk women by APTIMA Combo2 assay. Indian J Med Microbiol. 2013 Jan-Mar;31(1):96-7. doi: 10.4103/0255-0857.108756. PMID: 23508446.

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    41. Rao G, Das A, Prabhakar P, Nema V, Risbud AR. Alteration in sample preparation to increase the yield of multiplex Polymerase Chain Reaction assay for diagnosis of genital ulcer disease. Indian J Med Microbiol. 2013 Jan-Mar;31(1):15-8. doi: 10.4103/0255-0857.108709. PMID: 23508423.

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    42. Prabhakar P, Narayanan P, Deshpande GR, Das A, Neilsen G, Mehendale S, Risbud A. Genital ulcer disease in India: etiologies and performance of current syndrome guidelines. Sex Transm Dis. 2012 Nov;39(11):906-10. doi: 10.1097/OLQ.0b013e3182663e22. PMID: 23064541.

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    43. Das A, Pathni AK, Narayanan P, George B, Morineau G, Saidel T, Prabhakar P, Deshpande GR, Gangakhedkar R, Mehendale S, Risbud A. High rates of reinfection and incidence of bacterial sexually transmitted infections in a cohort of female sex workers from two Indian cities: need for different STI control strategies? Sex Transm Infect. 2013 Feb;89(1):5-10. doi: 10.1136/sextrans-2012-050472. Epub 2012 Nov 29. PMID: 23196329; PMCID: PMC3582065.

  • 44. Narayanan, P. and Das, A. and Prabhakar, P. and Gurung, A. and Morineau, G. and Rao, G. and Gangakhedkar, R. and Risbud, A. Self-identity, sexual practices and sexually transmitted infections among high-risk men who have sex with men attending clinics in Urban India. Journal of AIDS and Clinical Research. 2012. Volume 3, Issue SPL ISS1A. DOI: 10.4172/2155-6113.S1-011.

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    45. Das A, Prabhakar P, Narayanan P, Neilsen G, Wi T, Kumta S, Rao G, Gangakhedkar R, Risbud A. Prevalence and assessment of clinical management of sexually transmitted infections among female sex workers in two cities of India. Infect Dis Obstet Gynecol. 2011;2011:494769. doi: 10.1155/2011/494769. Epub 2011 Jun 22. PMID: 21747642; PMCID: PMC3124070.

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    46. Raju, S., Rao, G., Patil, S. A, & Kelmani, C. R. (2007). Increase in cell size and acid tolerance response in a stepwise-adapted methicillin resistant Staphylococcus aureus mutant. World journal of microbiology & biotechnology, 23, 1227-1232. doi: 10.1007/s11274-007-9352-4.

 

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