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Dr Anuradha Tripathy

HomeDr Anuradha Tripathy
HomeDr Anuradha Tripathy
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Dr. Anuradha Tripathy

Designation: Scientist F,

Division: Hepatitis

Educational qualifications: M.Sc. Ph.D.

Date of joining ICMR-NIV: 21 April 2005

  • Contact: 020-26006823
  • Email: anuradhastripathy@hotmail.com
  • Office: Indian Council of Medical Research-National Institute of Virology Pune Maharashtra - 411001

 

Research Interests:

Viral disease pathogenesis, Host immune response in viral diseases, vaccine, Immune correlates of protection, Biomarker of severity/recovery in viral infections

 

Awards/Honours:

  • Awarded gold medal for securing Ist position in M.Sc.
  • Awarded National open Merit Scholarship for SSC
  • Awarded open Merit Scholarship for HSC

 

ORCID ID:#

Researcher ID: #

Google Scholar Profile Link

 

List of Publications
  • 1.Tripathy AS*, Trimbake D. Suryawanshi PV, Tripathy SP, Gurav YK, Potdar VA,  Chaudhary ML,. Athavale P, Mokashi ND, Patsute SD, Kakrani AL and Abraham PA. Higher numbers of Th, Tc cells and lower numbers of NK cells correlate with resolving mild SARS‑CoV‑2 infection. IJMR. 2021

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    2. Yadav PD, etal. Assessment of immunogenicity and protective efficacy of ZyCoV-D DNA vaccine candidates in Rhesus macaques against SARS-CoV-2 infection. bioRxiv. 2021 Jan 1.DOI: https://doi.org/10.1101/2021.02.02.429480

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    3. Tripathy AS*,Vishwakarma S, Trimbake D, Gurav YK, Potdar VA, Mokashi ND, Patsute SD, Kaushal H, Chaudhary ML,. Tilekar BN, PD Sarje, VS. Dange, P Abraham Pro-inflammatory CXCL-10, TNF-α, IL-1β and IL-6: Biomarkers of SARS-CoV-2 infection. Archives of Virology. 2021. 10.1007/s00705-021-05247-z

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    4. Pavitrikar DV, Atre NM, Tripathy AS & Shil P.  Cyclophilin A: A possible host modulator in Chandipura virus infection. Archives of Virology2021

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    5. Pavitrikar DV, Atre NM, Tripathy AS & Shil P. Design of a multi-epitope peptide vaccine candidate against Chandipura Virus: an immuno-informatics study. J Biomol Struct Dyn. 2020 Sep 8;1-12. doi: 10.1080/07391102.2020.1816493

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    6. Tripathy AS*, Sharma M, Thorat NC, Jadhav S & Koshatwar KA. An Outbreak of hepatitis E in Yavatmal, India, 2019. J Med Virol. 2021 doi: 10.1002/jmv.26377.

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    7. Gupta P & Tripathy AS*. Alternative pathway of complement activation has a beneficial role against Chandipura virus infection. Medical Microbiology and Immunology. 2019. DOI: 10.1007/s00430-019-00648-z.

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    8. Tripathy AS*, Ganu MA, Sonam Lata, Alagarasu K, WalimbeAM, Thanapati S, Gupta P, & Puranik S Association of IL-1RN VNTR Polymorphism with Chikungunya Infection: A Study from Western India. J Med Virol, 2019. DOI: 10.1002/jmv.25546

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    9. Tripathy AS*, Sharma M, Deoshatwar AR, Babar P, Bharadwaj R, OK Bharti. "Molecular characterization of hepatitis E virus from an outbreak mediated by mixing of virus contaminated water with drinking water supply in Shimla, India, 2015-16”. Transactions of the Royal Society of Tropical Medicine and Hygiene, 2019. DOI:10.1093/trstmh/trz072

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    10. Kulkarni SP, Sharma M & Tripathy AS*. Antibody and memory B cell responses in hepatitis E recovered individuals; 1-30 years post Hepatitis E Virus infection. Scientific Reports. 2019 Mar 1

  • 11. 1;9(1):4090. doi: 10.1038/s41598-019-40603-9Tripathy AS*, Puranik S, Sharma M, Chakraborty S & Dekate U. Hepatitis E virus seroprevalence among blood donors in Pune, India. J Med Virol.2018 doi: 10.1002/jmv.25370. Epub 2018 Dec 17.

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    12. Pavitrakar DV, Damle RG, Tripathy AS & Shil P. Identification of a conserved neutralizing epitope in the G-protein of Chandipura virus. Archives of Virology, 2018, https://doi.org/10.1007/s00705-018-3987-3

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    13. Thanapati S, Ganu M & Tripathy AS* Differential inhibitory and activating NK cell receptor levels and NK/NKT-like cell functionality in chronic and recovered stages of chikungunya. PLOS ONE, 2017, https://doi.org/10.1371/journal.pone.0188342 November 28,

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    14. Thanapati S Sudeep AB, Kulkarni SP & Tripathy AS*. Regulation of the chikungunya virus induced innate inflammatory response by protein tyrosine phosphatase non-receptor 6 in muscle cells. Archives of Virology, 2017 , 10.1007/s00705-017-3615-7

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    15. Kulkarni SP, Ganu M, Jayawant P, Thanapati S, Ganu A & Tripathy AS* .Regulatory T cells and IL-10 as modulators of chikungunya disease outcome: a preliminary study. Eur J Clin Microbiol Infect Dis,2017, DOI: 10.1007/s10096-017-3087-4  

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    16. Thanapati S, Ganu M, Giri P, Kulkarni S, Sharma M, Babar P, Ganu & Tripathy AS*. Impaired NK cell functionality and increased TNF-α production as biomarkers of chronic chikungunya arthritis and rheumatoid arthritis. Human Immunology, 2017, 10.1016/j.humimm.2017.02.006

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    17. Kulkarni SP, Thanapati S, Arankalle VA & Tripathy AS*. Specific memory B cell response and participation of CD4+ central and effector memory T cells in mice immunized with liposome encapsulated recombinant NE protein based Hepatitis E vaccine candidate. Vaccine, 2016,34 5895-5902.

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    18. Rathod SB & Tripathy AS*. TGF-<beta>1 and contact mediated suppression by CD4+CD25+CD127- T regulatory cells of patients with self-limiting hepatitis E. Human Immunology, 2016, 77,1254-1263

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    19. Tillu H, Tripathy AS*, Reshmi PV & D Cecilia. Altered profile of regulatory T cells and associated cytokines in mild and moderate dengue. Eur J Clin Microbiol Infect Dis,2016, 35:453-461

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    20. Rathod SB & Tripathy AS*. TGF-β1 gene -509C>T promoter polymorphism modulates TGF-β1 levels in Hepatitis E patients. Metagene, 2015, Sept 15;6:53-8.

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    21. Thanapati S, Das R & Tripathy AS*. Phenotypic and functional analyses of NK and NKT-like populations during early stages of Chikungunya virus infection. Frontiers in Microbiology, 01 September 2015 | http://dx.doi.org/10.3389/fmicb.2015.00895

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    22. Tripathy AS*, Tandale BV, Balaji SS, Hundekar SL, Ramdasi AY & Arankalle VA. Envelope specific T cell response and cytokine profiles in Chikungunya patients from India, hospitalized with different clinical presentations. Ind. J Med. Res ,2015, Feb, pp 205-212

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    23. Dhayarkar S, Chadha M, Tripathy A, Jadhav S, Deshmukh N & Mehendale S. Outbreak of waterborne Hepatitis E, Pune, Maharashtra, India, 2013. Indian Journal of Community and Family Medicine, 2015, vol 1, issue 1

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    24. Rathod S & Tripathy AS*. Hepatitis E rORF2p stimulated and unstimulated peripheral expression profiling in patients with self-limiting Hepatitis E infection. J of Immunological Research, 2014, http://dx.doi.org/10.1155/2014/565284

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    25. Das R & Tripathy AS*. Increased expressions of NKp44, NKp46 on NK/NKT like cells are associated with impaired cytolytic function in self-limiting Hepatitis E infection. Medical Microbiology and Immunology, 2014, DOI: 10.1007/s00430-014-0338-1

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    26. Thanapati S, Hande A, Das R, Gurav YK &Tripathy AS*.Association of HLA Class II allele and haplotypes in Chikungunya viral infection in a Western-Indian Population. Transactions of the Royal Society of Tropical Medicine and Hygiene, 2014 doi:10.1093/trstmh/tru030

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    27. Rathod SB, Das R, Thanapati S, Arankalle VA & Tripathy AS*.Suppressive activity and altered conventional phenotype markers/mediators of regulatory T cells in patients with self-limiting Hepatitis E. Journal of Viral Hepatitis, 2013, 21, 141–151

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    28. Das R, Rathod SB, Alagarasu K, Arankalle VA & Tripathy AS*. Altered expressions of peripheral CD11c, CD80, CD83 markers and associations of HLA class II allele and haplotypes in self-limiting Hepatitis E infection. Hum Immunol. 2013; 74: 277-285

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    29. Mahapatra C & Tripathy AS*. Antigen specific cellular response in patients with hepatitis C virus infection and its association with HLA alleles. Advanced Research Journal of Immunology and Virology Vol. 1 (1), pp. 014-026, September, 2013.

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    30. Tripathy AS*, Das R, Rathod SB & Arankalle VA. Cytokine profiles, CTL response and phenotype T cell frequencies in the peripheral blood of self-limiting acute patients & individuals recovered from Hepatitis E infection. Plos ONE 20127(2):e31822. Epub  Feb 22

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    31. Tripathy AS*, Das R, Rathod SB, Gurav YK & Arankalle VA. Peripheral T regulatory cells and cytokines in Hepatitis E infection. European Journal of Clinical Microbiology & Infectious Disease 2011 (DOI 10.1007/s10096-011-1291-1 )

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    32. Tripathy AS*, Das R, Chadha MS & Arankalle VA. Epidemic of Hepatitis B with high mortality in India: Association of fulminant disease with lack of CCL4 & Natural Killer T cells. Journal of Viral Hepatitis, 2011, 18, e415–e422

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    33. Arankalle VA, Lole KS, Arya R, Tripathy AS, Ramdasi AY, Chadha MS, Sangle SA & Kadam DB. Role of host immune response and viral load in the differential outcome of pandemic H1N1 (2009) influenza virus infection in Indian patients. 1st Oct. PLoS ONE 2010 5(10): e13099, doi:10.1371

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    34. Priyadarshini D, Gadia RR, Tripathy A, Gurukumar KR, Bhagat A, et al. Clinical Findings and Pro-Inflammatory Cytokines in Dengue Patients in Western India: A Facility-Based Study. 14 Jan, PLoS ONE 2010, 5(1): e8709.

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    35. Saravanabalaji S, Tripathy AS., Dhoot, RR, Chadha, MS., Kakrani, AL. & Arankalle VA. Viral load antibody titers and recombinant open reading frame 2 protein-induced Th1/Th2 cytokines and cellular immune responses in self- limiting and fulminant hepatitis E. Intervirology. 2009 52 78

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    36. Shrivastava S, Lole KS, Tripathy AS & VA Arankalle. A Development of candidate combination vaccine for hepatitis E and hepatitis B: A liposome encapsulation approach.  Vaccine. 2009, 27: 42, 25.

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    37. Tripathy AS, Shankarkumar U, Chadha MS, Ghosh K & Arankalle VA. HLA alleles associated with Hepatitis C Virus infection in Maharashtra, Western India. Ind. J Med. Res. 2009,130, November pp 550-555

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    38. Tandale BV, Sathe PS, Arankalle VA, Wadia RS, Kulkarni R, Shah SV, Shah SK, Seth JK, Sudeep AB, Tripathy AS, Mishra. AC. Systemic involvements and deaths in Chikungunya in India. J Clin. Virol. 2009, Oct; 46(2):145-9. Epub Jul 28.

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    39. Deshmukh TM, Lole KS, Tripathy AS, Arankalle VA. Immunogenicity of candidate hepatitis E virus DNA vaccine expressing complete and truncated ORF2 in mice. Vaccine. 2007 30; 25: 4 350-60.

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    40. Tripathy A, Balaji S, Rao N, Thakare J, Mishra A, Arankalle V. Cytokine levels in Chandipura virus associated encephalopathy in children. Scand J Infect Dis. 2005; 37: 590-3

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    41. Tripathy A, Chadha MS, Arankalle VA. Cytokine profiles in peripheral blood mononuclear cells and sera from patients with acute self-limited hepatitis A. Acta Virol. 2005:49: 283-4.

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    42. Mishra A, Rao KV, Durgapal H, Manivel V, Panda SK. Human T-helper cell responses to a synthetic peptide derived from the hepatitis B surface antigen. Immunology. 1993 Jul; 79:362-7

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    43. Manivel V, Tripathy A, Durgapal H, Kumar A, Panda SK, Rao KV. A self-associating hepatitis B surface antigen-derived peptide that is immunogenic in alum. Vaccine 1993; 11: 366-71

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    44. Mishra A, Durgapal H, Manivel V, Acharya SK, Rao KV, Panda SK. Immune response to hepatitis B virus surface antigen peptides during HBV infection. Clin Exp Immunol. 1992; 90:194-8.

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    45. Mishra (Tripathy) A, Rao KVS, Durgapal H, Manivel V, Panda SK. Human T-helper-cell responses to a synthetic peptide derived from the hepatitis B surface antigen. Recombinant and Synthetic Vaccines edited by G.P. Talwar et al. Narosa Publishing House, New Delhi, 1993.

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    46. VA Arankalle, KS Lole, AS Tripathy &TM Deshmukh. “Hepatitis Viruses” in the Golden Jubilee publication of NIV. Published in December, 2012 on the occasion of golden to Diamond Jubilee: The Glorious Decade of NIV.

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    47. Tripathy AS & Alagarasu KA. ‘Immunological Techniques” in the Technical Manual published in December, 2012, on the occasion of golden to Diamond Jubilee: The Glorious Decade of NIV.

    Corresponding author

 

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